Denis Noble
| Denis Noble | |
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| Born | 16 November 1936 |
| Residence | UK |
| Nationality | British |
| Fields | |
| Institutions | University of Oxford |
| Alma mater | University College London (BSc, MA, PhD) |
| Thesis | Ion conductance of cardiac muscle (1961) |
| Doctoral advisor | Otto Hutter |
| Notable awards | |
| Spouse | Susan Jennifer Barfield |
| Children | one son, one daughter |
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Denis Noble CBE FRS FRCP FMedSci (born 16 November 1936) is a British biologist who held the Burdon Sanderson Chair of Cardiovascular Physiology at the University of Oxford from 1984 to 2004 and was appointed Professor Emeritus and co-Director of Computational Physiology. He is one of the pioneers of Systems Biology and developed the first viable mathematical model of the working heart in 1960.
Noble was educated at Emanuel School and University College London (UCL). In 1958 he began his investigations into the mechanisms of heartbeat. This led to two seminal papers in Nature in 1960 giving the first proper simulation of the heart. From this work it became clear that there was not a single oscillator which controlled heartbeat, but rather this was an emergent property of the feedback loops in the various channels. In 1961 he obtained his PhD working under the supervision of Otto Hutter at UCL.
Noble's research focuses on using computer models of biological organs and organ systems to interpret function from the molecular level to the whole organism. Together with international collaborators, his team has used supercomputers to create the first virtual organ, the virtual heart.
As Secretary-General of the International Union of Physiological Sciences 1993-2001, he played a major role in launching the Physiome Project, an international project to use computer simulations to create the quantitative physiological models necessary to interpret the genome, and he was elected President of the IUPS at its world congress in Kyoto in 2009
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