Deferoxamine

Deferoxamine

Skeletal formula and spacefill model of deferoxamine
Clinical data
Trade names	Desferal
AHFS/Drugs.com	Monograph
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	intramuscular intravenous subcutaneous
ATC code	V03AC01 (WHO)
Pharmacokinetic data
Biological half-life	6 hours
Identifiers
IUPAC name N'-{5-[Acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxysuccinamide
Synonyms	desferrioxamine B, desferoxamine B, DFO-B, DFB ,N'-[5-(Acetyl-hydroxy-amino)pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide
CAS Number	70-51-9
PubChem CID	2973
DrugBank	DB00746
ChemSpider	2867
UNII	J06Y7MXW4D
KEGG	D03670
ChEBI	CHEBI:4356
ChEMBL	CHEMBL556
ECHA InfoCard	100.000.671
Chemical and physical data
Formula	C25H48N6O8
Molar mass	560.69 g·mol−1
3D model (Jmol)	Interactive image
SMILES Cc(:[o]):n(:[oH])CCCCC[nH]:c(:[o])CCc(:[o]):n(:[oH])CCCCC[nH]:c(:[o])CCc(:[o]):n(:[oH])CCCCCN
InChI InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34)  Y Key:UBQYURCVBFRUQT-UHFFFAOYSA-N

Deferoxamine (DFOA), sold under the brand name Desferal, is a medication that binds iron and aluminium. It is specifically used in iron overdose, hemochromatosis either due to multiple blood transfusions or an underlying genetic condition, and aluminium toxicity in people on dialysis. It is used by injection into a muscle, vein, or under the skin.

Common side effects include pain at the site of injection, diarrhea, vomiting, fever, hearing loss, and eye problems. Severe allergic reactions including anaphylaxis and low blood pressure may occur. It is unclear if use during pregnancy or breastfeeding is safe for the baby. Deferoxamine is a siderophore from the bacteria Streptomyces pilosus.

Deferoxamine was approved for medical use in the United States in 1968. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 6.76 to 13.52 USD per dose. In the United States a course of treatment costs more than 200 USD.