Deerbrook is an unincorporated community in Noxubee County, in the U.S. state of Mississippi.
A post office was established as "Deer Brook" in 1842. The name was changed to "Deerbrook" in 1856, and the post office was discontinued in 1942.
Deerbrook had a population of 66 by 1900. The settlement was described as having "two stores, and a fine cotton gin."
Chemist Charles Baskerville was born in Deerbrook.
Coordinates: 33°14′07″N 88°29′12″W / 33.23528°N 88.48667°W