"Deep Six" is a song by American rock band Marilyn Manson. The song was released to digital outlets on December 16, 2014 as the second single from the band's ninth studio album, The Pale Emperor (2015). A music video directed by Bart Hess was released on YouTube. The song was a hit on American Active Rock radio, peaking at number eight on Billboard's Mainstream Rock, becoming the band's highest peaking single ever on that chart.

Tim Noakes of Dazed Digital wrote that the song is about "sin and sex."

The song was released as a one-track single via music download services on December 16, 2014, as the second single taken from the album. A limited edition CD was released exclusively at Best Buy stores in the US a week later on December 23, containing both "Deep Six" and the album's other single, "Third Day of a Seven Day Binge", as double A-sides. A limited amount of these CDs came bundled with an exclusive T-shirt. "Deep Six" also appeared on the soundtrack to the video game WWE 2K16.

A music video directed by textile design artist Bart Hess was released on to YouTube on December 19 to promote the single. Despite often being described as making heavy-use of computer-generated imagery, Hess has said on his Facebook account that the video was made "without the use of any CGI." The video is inspired by the snake-on-a-staircase scene from Beetlejuice, with the "snake" imagery based on textured fabric designs Hess had previously created. The music video features dancer Amy Gilson and Burlesque artist Olivia Bellafontaine. As of December 2016, the video has received 16 million views on YouTube.

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