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Davis–Beirut reaction


In chemistry the Davis–Beirut reaction is an annulation reaction first reported by Mark Kurth and Makhluf Haddadin in 2005. It is named after their respective universities; University of California, Davis and American University of Beirut.

The reaction originally produced N2-substituted-indazalones, by a reaction between o-nitrosobenzaldehyde and primary amines, under basic conditions. It has subsequently been expanded to produce a variety of 3-hetero-indazoles from a boarder range of starting materials under acidic or basic conditions.



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