David Barclay of Cheapside (1682–1769) was a Scottish merchant and banker.
He was the second son of Robert Barclay, the Scottish Quaker writer, and was active in the Society of Friends. An apprentice in London in 1698, he became a leading linen merchant. Involved in banking through a family connection with John Freame, father of his second wife, Barclay was not directly concerned with the firm that much later became Barclays Bank; but two of his sons were, John and David.
Success in business brought Barclay a fortune of £100,000 at his death. He lived opposite St Mary-le-Bow, and was noted for his hospitality to Quaker ministers.
Barclay had 14 children: six (two sons and four daughters) by his first marriage to Anne Taylor (died 1720), and eight (two sons and four daughters) by his second wife Priscilla Freame, daughter of John Freame, whom he married in 1723.