Dan O'Brien Sr. (March 26, 1929 – January 16, 2017) was a front office executive in Major League and minor league baseball. He was the father of Dan O'Brien Jr., a former MLB general manager and scouting director.
O'Brien attended Seton Hall University and graduated from Florida Southern College. He was a general manager in the minor leagues from 1955–63 in the Pittsburgh Pirates and Milwaukee Braves organizations, then spent another nine years (1964–72) as assistant to Phil Piton and Hank Peters, presidents at the time of the National Association of Professional Baseball Leagues, the minor leagues' governing body.
O'Brien came to the Major Leagues when he joined the Texas Rangers as a vice president during its 1973 season, and was promoted to general manager of the Rangers later that season; he would continue in that post through 1978, although he shared power with co-general manager Eddie Robinson in 1977–78.
In 1979, O'Brien became president of the Seattle Mariners, then in their third year as an American League expansion team, and he added the general manager title to his duties from 1981–83, replacing Lou Gorman. He left Seattle in 1984 and joined the front office of the Cleveland Indians in 1986, working with Peters again as his top assistant in 1987–89.