Cystic
| Cyst | |
|---|---|
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| Micrograph of a mediastinal bronchogenic cyst. H&E stain. | |
| Classification and external resources | |
| Specialty | Pathology, general surgery |
| MedlinePlus | 003240 |
| MeSH | D003560 |
A cyst is a closed , having a distinct membrane and division compared to the nearby tissue. Hence, it is a cluster of cells that have grouped together to form a sac (not unlike the manner in which water molecules group together, forming a bubble); however, the distinguishing aspect of a cyst is that the cells forming the "shell" of such a sac are distinctly abnormal (in both appearance and behaviour) when compared to all surrounding cells for that given location. It may contain air, fluids, or semi-solid material. A collection of pus is called an abscess, not a cyst. Once formed, a cyst may sometimes resolve on its own. When a cyst fails to resolve it may need to be removed by surgery but this will depend on what type of cyst it is and where in the body it has formed. Cancer-related cysts are formed as a defense mechanism for the body, following the development of mutations that lead to an uncontrolled cellular division. Once that mutation has occurred, the affected cells divide incessantly (and become known as cancerous), forming a tumour. The body encapsulates those cells to try and prevent them from continuing their division and try and contain the tumour, which becomes known as a cyst. That said, the cancerous cells can still mutate further and gain the ability to form their own blood vessels, from which they received nourishment before being contained. Once that happens, the capsule becomes useless and the tumour can go from benign to a cancer.
Some cysts are neoplastic and are thus called cystic tumors; many types are not neoplastic. Some are dysplastic or metaplastic. Pseudocysts are similar to cysts (having a sac filled with fluid) but lack an epithelial lining.
The aneurysmal bone cyst is a neoplastic cyst, more specifically an aggressive lesion with radiographic cystic appearance.
Despite being described in 1938 as the microscopic appearance of cysts in the pancreas,cystic fibrosis is an example of a genetic disorder whose name is related to fibrosis of the cystic duct (which serves the gallbladder) and does not involve actual cysts.
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