Cross is James Patterson's 12th novel featuring his most famous character, Alex Cross. It was released in 2006. This novel was also released in some markets under the title Alex Cross.
Patterson portrays him as a lonely person but also as a model father who tries to spend as much time as possible with his family.
Her real name is Regina Hope Cross and she’s Alex’s grandmother who looked after him when he grew up. She’s 81 years old and still lives with Alex and his three children in Washington DC. Nana used to work as an English teacher and as an assistant principal at Garfield North Junior High School in Washington. She’s quite severe and manners are very important for her. She helped take care of Alex and his kids after Maria died.
Alex's deceased wife, whom we briefly meet in the opening chapters of the story. She is shown in a flashback in the very beginning of the story and also in another mini-flashback in the middle of the story. Maria was a kind, gentle, and loving woman. She is the mother of Janelle and Damon, who she loved with all of her heart. She was even pregnant with her and Alex's third child. She loved Alex very much, even telling him this just before she died.
In the novel, it is revealed that John killed Maria's real murderer, Jimmy "Hats" Galati, along with the help of a fellow detective named Rakeem Powell, in New York City. John and Rakeem covered up the murder, so that no one would find out. When John reveals this to Alex, it helps strengthens their friendship and the two decide to keep the truth buried.
Kayla is a resident physician at a local hospital in Southeast Washington D.C. and also Alex's girlfriend in the novel. She was introduced in Four Blind Mice and appears all the way to Cross, during which, she and Alex form an attraction to each other and later start dating in Mary Mary. Kayla has romantic feelings for Alex and enjoys being with him.
During the story, she is stabbed by a junkie and is taken to the hospital, where Alex comforts her. While visiting her parents in her hometown of North Carolina, Kayla decides to move back there, finding that she can do more good there and later tells Alex, who is sadden by this but supports her. By the end of the novel, Kayla tries to convince Alex to move with her, showing that she still wants a relationship with him, but Alex refuses, believing that he can never leave Washington behind. Kayla and Alex decide to end their relationship, which saddens them both, and they go their separate ways.