Coversyl Plus
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|
| Combination of | |
|---|---|
| Perindopril | ACE inhibitor |
| Indapamide | Thiazide-like diuretic |
| Clinical data | |
| Trade names | Preterax, Noliprel |
| Routes of administration |
Oral (tablets) |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| PubChem CID | |
| ChemSpider | |
Perindopril/indapamide (marketed as Preterax and Noliprel) is a combination drug used for the treatment of essential hypertension.
Each scored tablet contains 2 mg of perindopril tert-butylamine salt and 0.625 mg of indapamide.
One tablet daily, preferably to be taken in the morning and before a meal.
Elderly patients: Normal dosage.
Renal failure: Creatinine clearance (CrCl) >30 mL/min: no dosage modification. If CrCl <30 mL/min, treatment is contraindicated.
Using a fixed combination of an ACE inhibitor and a chlorosulfamoyl diuretic leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately, in addition to those due to the additive synergistic action of the two constituents, when combined, on vascular endothelium, arteriolocapillary microcirculation, and the target organs of hypertension.
Absolute: Known allergy to perindopril, indapamide, or sulfonamides; history of Quincke's edema linked to previous ACE inhibitor therapy; end-stage renal disease; serious liver disorder; hyperkalemia; pregnancy; lactation. Relative: Combination therapy with lithium, potassium salts, potassium-sparing diuretics, and certain medicines which can cause heart rhythm disorders.
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