Coptic Cairo is a part of Old Cairo which encompasses the Babylon Fortress, the Coptic Museum, the Hanging Church, the Greek Church of St. George and many other Coptic churches and historical sites. It is believed in Christian tradition that the Holy Family visited this area and stayed at the site of Saints Sergius and Bacchus Church (Abu Serga). Coptic Cairo was a stronghold for Christianity in Egypt until the Islamic era, though most of the current buildings of the churches in Coptic Cairo were built after the Muslim conquest of Egypt.
There is evidence of settlement in the area as early as the 6th century BC, when Persians built a fort on the Nile, north of Memphis. The Persians also built a canal from the Nile (at Fustat) to the Red Sea. The Persian settlement was called Babylon, reminiscent of the ancient city along the Euphrates, and it gained importance while the nearby city of Memphis declined, as did Heliopolis. During the Ptolemaic period, Babylon and its people were mostly forgotten.
It is traditionally held that the Holy Family visited the area during the Flight into Egypt, seeking refuge from Herod. Further it is held that Christianity began to spread in Egypt when St. Mark arrived in Alexandria, becoming the first Patriarch, though the religion remained underground during the rule of the Romans. As the local population began to organize towards a revolt, the Romans, recognising the strategic importance of the region, took over the fort and relocated it nearby as the Babylon Fortress.Trajan reopened the canal to the Red Sea, bringing increased trade, though Egypt remained a backwater as far as the Romans were concerned.