Cone cells

Cone cell
Normalized responsivity spectra of human cone cells, S, M, and L types
Details
Function	Colour vision
Identifiers
Code	TH H3.11.08.3.01046
NeuroLex ID	Cone Cell
Anatomical terminology []

Cone cells, or cones, are one of three types of photoreceptor cells in the retina of mammalian eyes (eg the human eye). They are responsible for color vision and function best in relatively bright light, as opposed to rod cells, which work better in dim light. Cone cells are densely packed in the fovea centralis, a 0.3 mm diameter rod-free area with very thin, densely packed cones which quickly reduce in number towards the periphery of the retina. There are about six to seven million cones in a human eye and are most concentrated towards the macula. The commonly cited figure of six million cone cells in the human eye was found by Osterberg in 1935. Oyster's textbook (1999) cites work by Curcio et al. (1990) indicating an average close to 4.5 million cone cells and 90 million rod cells in the human retina.

Cones are less sensitive to light than the rod cells in the retina (which support vision at low light levels), but allow the perception of colour. They are also able to perceive finer detail and more rapid changes in images, because their response times to stimuli are faster than those of rods. Cones are normally one of the three types, each with different pigment, namely: S-cones, M-cones and L-cones. Each cone is therefore sensitive to visible wavelengths of light that correspond to short-wavelength, medium-wavelength and long-wavelength light. Because humans usually have three kinds of cones with different photopsins, which have different response curves and thus respond to variation in colour in different ways, we have trichromatic vision. Being colour blind can change this, and there have been some verified reports of people with four or more types of cones, giving them tetrachromatic vision. The three pigments responsible for detecting light have been shown to vary in their exact chemical composition due to genetic mutation; different individuals will have cones with different color sensitivity. Destruction of the cone cells from disease would result in blindness.