O Comércio do Porto (lit. Porto Trade) was a Portuguese daily newspaper, founded in Porto on 2 June 1854. It was the second-oldest newspaper published in Portugal, second only to O Açoriano Oriental.
Following a large drop in readership in the 1990s, it was published in its later years as a regional newspaper only. Its last edition was printed on 30 July 2005.
Its last director was António Matos.