Coenzyme F420

Coenzyme F₄₂₀ or 8-hydroxy-5-deazaflavin is a coenzyme involved in redox reactions in methanogens, in many Actinobacteria, and sporadically in other bacterial lineages. It is a flavin derivative. The coenzyme is a substrate for coenzyme F₄₂₀ hydrogenase,5,10-methylenetetrahydromethanopterin reductase and methylenetetrahydromethanopterin dehydrogenase.

A particularly rich natural source of F₄₂₀ is Mycobacterium smegmatis, in which several dozen enzymes use F₄₂₀ instead of the related cofactor FMN used by homologous enzymes in most other species.

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