Defileul Dunării, also locally known as Clisura Dunării (Serbian: Банатска Клисура, Banatska Klisura) is a geographical region in Romania. It is located in southern Banat, along the northern bank of the river Danube. Clisura Dunării is situated between river Nera in the west, and Gura Văii or Cazanele Dunării in the east.
The area includes the municipality of Orşova and the town of Moldova Nouă, as well as several communes (Socol, Pojejena, Coronini, Gârnic, Sicheviţa, Berzasca, Sviniţa, Dubova, Eşelniţa, Iloviţa, and Brezniţa-Ocol).
The Romanian name is Defileul Dunării. River Danube is called Dunărea in Romanian. The sometimes used local name clisura derives from Serbian; Klisura means "pass", "gorge", "gate" and "sharp rock" in Serbian. It is derived from the Greek , which in turn derives from the Latin clausura, meaning "closed entity", ide est "monastery, castle, fort". The term was applied by the Byzantines to fortified mountain districts controlling important passes.