Claysville is an unincorporated community in Guernsey County, in the U.S. state of Ohio.
Claysville was platted in 1828 on the Clay Pike, from which the community took its name. A post office called Claysville has been in operation since 1830.
Coordinates: 39°56′10″N 81°40′13″W / 39.93611°N 81.67028°W