Claudia de' Medici (4 June 1604 – 25 December 1648) was Regent of the Austrian County of Tyrol during the minority of her son from 1632 until 1646. She was a daughter of Ferdinando I de' Medici, Grand Duke of Tuscany and Christina of Lorraine. She was born in Florence, and was named after her grandmother Claude of Valois, herself granddaughter of Claude, Duchess of Brittany, consort to King Francis I of France.

In 1620, she married Federico Ubaldo della Rovere, the only son of Francesco Maria II della Rovere, Duke of Urbino. Their only child went on to marry the Grand Duke of Tuscany. Federico Ubaldo della Rovere died suddenly on 29 June 1623.

After her husband's premature death, she was married, on 19 April 1626, to Leopold V, Archduke of Austria, and thus became Archduchess consort of Austria. She died at Innsbruck in 1648.

On the death of her husband in 1632, she assumed a regency in the name of her son Ferdinand Charles who was the ruler of the Princely County of Tyrol. Claudia, along with five directors, held the post until 1646.

She had one child by Federico Ubaldo della Rovere:

She had five children by Leopold V:

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