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Cisplatin

Cisplatin
Cisplatin-stereo.svg
Cisplatin-3D-vdW.png
Clinical data
Trade names Platinol, others
AHFS/Drugs.com Monograph
MedlinePlus a684036
Pregnancy
category
  • US: D (Evidence of risk)
Routes of
administration
Intravenous
ATC code L01XA01 (WHO)
Legal status
Legal status
Pharmacokinetic data
Bioavailability 100% (IV)
Protein binding > 95%
Biological half-life 30–100 hours
Excretion Renal
Identifiers
Synonyms cisplatinum, platamin, neoplatin, cismaplat, cis-diamminedichloridoplatinum(II) (CDDP)
CAS Number 15663-27-1 YesY
PubChem (CID) 84691
DrugBank DB00515 YesY
ChemSpider 76401 N
UNII Q20Q21Q62J YesY
KEGG D00275 YesY
ChEBI CHEBI:27899 YesY
ChEMBL CHEMBL2068237 N
PDB ligand ID CPT (PDBe, RCSB PDB)
ECHA InfoCard 100.036.106
Chemical and physical data
Formula [Pt(NH3)2Cl2]
Molar mass 300.01 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  

Cisplatin is a chemotherapy medication used to treat a number of cancers. This includes testicular cancer, ovarian cancer, breast cancer, bladder cancer, head and neck cancer, cervical cancer, lung cancer, mesothelioma, esophageal cancer, brain tumors, and neuroblastoma. It is used by injection into a vein.

Common side effects include bone marrow suppression, hearing problems, kidney problems, and vomiting. Other serious side effects include numbness, trouble walking, allergic reactions, electrolyte problems, and heart disease. Use during pregnancy is known to harm the baby. Cisplatin is in the platinum-based antineoplastic family of medications. It works in part by binding to and blocking the duplication of DNA.

Cisplatin was discovered in 1845 and licensed for medical use in 1978. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 5.56 to 7.98 USD per 50 mg vial. In the United Kingdom this costs the NHS about 17 pounds.


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