Cisplatin
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| Clinical data | |
|---|---|
| Trade names | Platinol, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a684036 |
| Pregnancy category |
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| Routes of administration |
Intravenous |
| ATC code | L01XA01 (WHO) |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 100% (IV) |
| Protein binding | > 95% |
| Biological half-life | 30–100 hours |
| Excretion | Renal |
| Identifiers | |
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| Synonyms | cisplatinum, platamin, neoplatin, cismaplat, cis-diamminedichloridoplatinum(II) (CDDP) |
| CAS Number |
15663-27-1 
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| PubChem (CID) | 84691 |
| DrugBank |
DB00515
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| ChemSpider |
76401 
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| UNII |
Q20Q21Q62J
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| KEGG |
D00275
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| ChEBI |
CHEBI:27899
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| ChEMBL |
CHEMBL2068237
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| PDB ligand ID | CPT (PDBe, RCSB PDB) |
| ECHA InfoCard | 100.036.106 |
| Chemical and physical data | |
| Formula | [Pt(NH3)2Cl2] |
| Molar mass | 300.01 g/mol |
| 3D model (Jmol) | Interactive image |
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(what is this?)
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Cisplatin is a chemotherapy medication used to treat a number of cancers. This includes testicular cancer, ovarian cancer, breast cancer, bladder cancer, head and neck cancer, cervical cancer, lung cancer, mesothelioma, esophageal cancer, brain tumors, and neuroblastoma. It is used by injection into a vein.
Common side effects include bone marrow suppression, hearing problems, kidney problems, and vomiting. Other serious side effects include numbness, trouble walking, allergic reactions, electrolyte problems, and heart disease. Use during pregnancy is known to harm the baby. Cisplatin is in the platinum-based antineoplastic family of medications. It works in part by binding to and blocking the duplication of DNA.
Cisplatin was discovered in 1845 and licensed for medical use in 1978. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 5.56 to 7.98 USD per 50 mg vial. In the United Kingdom this costs the NHS about 17 pounds.
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