Cis-platin

Cisplatin

Clinical data
Trade names	Platinol, others
AHFS/Drugs.com	Monograph
MedlinePlus	a684036
Pregnancy category	US: D (Evidence of risk)
Routes of administration	Intravenous
ATC code	L01XA01 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	100% (IV)
Protein binding	> 95%
Biological half-life	30–100 hours
Excretion	Renal
Identifiers
IUPAC name (SP-4-2)-diamminedichloroplatinum(II)
Synonyms	cisplatinum, platamin, neoplatin, cismaplat, cis-diamminedichloridoplatinum(II) (CDDP)
CAS Number	15663-27-1 Y
PubChem (CID)	84691
DrugBank	DB00515 Y
ChemSpider	76401 N
UNII	Q20Q21Q62J Y
KEGG	D00275 Y
ChEBI	CHEBI:27899 Y
ChEMBL	CHEMBL2068237 N
PDB ligand ID	CPT (PDBe, RCSB PDB)
ECHA InfoCard	100.036.106
Chemical and physical data
Formula	[Pt(NH3)2Cl2]
Molar mass	300.01 g/mol
3D model (Jmol)	Interactive image
SMILES [NH3+][Pt-2]([NH3+])(Cl)Cl
InChI InChI=1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2 Y Key:LXZZYRPGZAFOLE-UHFFFAOYSA-L Y
NY (what is this?)

Cisplatin is a chemotherapy medication used to treat a number of cancers. This includes testicular cancer, ovarian cancer, breast cancer, bladder cancer, head and neck cancer, cervical cancer, lung cancer, mesothelioma, esophageal cancer, brain tumors, and neuroblastoma. It is used by injection into a vein.

Common side effects include bone marrow suppression, hearing problems, kidney problems, and vomiting. Other serious side effects include numbness, trouble walking, allergic reactions, electrolyte problems, and heart disease. Use during pregnancy is known to harm the baby. Cisplatin is in the platinum-based antineoplastic family of medications. It works in part by binding to and blocking the duplication of DNA.

Cisplatin was discovered in 1845 and licensed for medical use in 1978. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 5.56 to 7.98 USD per 50 mg vial. In the United Kingdom this costs the NHS about 17 pounds.