The Cirksena are a noble East Frisian family descended from a line of East Frisian chieftains from Greetsiel.
In 1439 in the wake of clashes between different lines of chieftains, the town of Emden was first placed by Hamburg under direct rule and then, in 1453, finally given to the Cirksenas. The family administered and ruled the town until 1595.
The Cirksena gained strength and succeeded the chieftain line of the tom Broks, after their opponent Focko Ukena was defeated and expelled by several allied chieftains, led by Edzard Cirksena. Ulrich Cirksena (d 1466) was elevated to the rank of imperial count by Emperor Frederick III and enfeoffed with the Imperial County of East Frisia.
The most important rule from the House of Cirksena was Edzard the Great (1462–1528), under whose leadership the Imperial County of East Frisia reached its greatest extent. During his reign the Reformation spread throughout East Frisia. In 1654 the Cirksena were elevated to princes by the emperor. Charles Edzard, the last ruler from the House of Cirksena, died without issue during the night of 25/26 May 1744 (reportedly from a glass of buttermilk, which he is said to have drunk after a hunt). Immediately thereafter, the state was taken over by Frederick the Great.