Chromosome five

Chromosome 5 (human)
Human chromosome 5 pair after G-banding. One is from mother, one is from father.
Chromosome 5 pair in human male karyogram.
Features
Length (bp)	181,538,259 bp (GRCh38)
No. of genes	839 (CCDS)
Type	Autosome
Centromere position	Submetacentric (48.8 Mbp)
External map viewers
Ensembl	Chromosome 5
Entrez	Chromosome 5
NCBI	Chromosome 5
UCSC	Chromosome 5
Full DNA sequences
RefSeq	NC_000005 (FASTA)
GenBank	CM000667 (FASTA)

Chromosome 5 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 5 spans about 181 million base pairs (the building blocks of DNA) and represents almost 6% of the total DNA in cells. Chromosome 5 is the 5th largest human chromosomes, yet has one of the lowest gene densities. This is partially explained by numerous gene-poor regions that display a remarkable degree of non-coding and syntenic conservation with non-mammalian vertebrates, suggesting they are functionally constrained.

Because chromosome 5 is responsible for many forms of growth and development (cell divisions) changes may cause cancers. One example would be acute myeloid leukemia (AML).

The following are some of the gene count estimates of human chromosome 5. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.

When simply saying "number of genes", in most cases, it refers only to "number of protein-coding genes".

The following are some of the genes located on chromosome 5:

The following are some of the diseases related to genes located on chromosome 5:

The following conditions are caused by changes in the structure or number of copies of chromosome 5: