Christiane Nusslein-Volhard
| Christiane Nüsslein-Volhard | |
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| Born |
20 October 1942 Magdeburg, Germany |
| Residence | Germany |
| Nationality | German |
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| Institutions | |
| Alma mater | University of Tübingen (PhD) |
| Thesis | Zur spezifischen Protein-Nukleinsäure-Wechselwirkung : die Bindung von RNS-Polymerase aus Escherichia coli an die Replikative-Form-DNS des Bakteriophagen fd und die Charakterisierung der Bindungsstellen (1974) |
| Doctoral advisor | Heinz Schaller |
| Notable awards | |
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Website www |
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Christiane Nüsslein-Volhard (born 20 October 1942) is a German biologist. She won the Albert Lasker Award for Basic Medical Research in 1991 and the Nobel Prize in Physiology or Medicine in 1995, together with Eric Wieschaus and Edward B. Lewis, for their research on the genetic control of embryonic development. Today she lives in Bebenhausen, Germany.
Nüsslein-Volhard was educated at the University of Tübingen where she was awarded a PhD in 1974 for research into Protein–DNA interactions and the binding of RNA polymerase in Escherichia coli.
The experiments that earned Nüsslein-Volhard and Wieschaus their Nobel prize aimed to identify genes involved in the development of Drosophila melanogaster (fruit fly) embryos. At this point (the late 1970s and early 1980s) little was known about the genetic and molecular mechanisms by which multicellular organisms develop from single cells to morphologically complex forms during embryogenesis.
Fruit flies have long been an important model organism in genetics due to their small size and quick generation time, which makes even large numbers of them relatively easy to maintain and observe in the laboratory. Nüsslein-Volhard and Wieschaus identified genes involved in embryonic development by a series of genetic screens. They generated random mutations in fruit flies using EMS (ethyl methanesulfonate). Some of these mutations affected genes involved in the development of the embryo. Nüsslein-Volhard and Weischaus took advantage of the segmented form of Drosophila larvae to address the logic of the genes controlling development. In normal unmutated Drosophila, each segment produces bristles called denticles in a band arranged on the side of the segment closer to the head (the anterior). The researchers looked at the pattern of segments and denticles in each mutant under the microscope, and were therefore able to work out that particular genes were involved in different processes during development based on their differing mutant phenotypes (such as fewer segments, gaps in the normal segment pattern, and alterations in the patterns of denticles on the segments). Many of these genes were given descriptive names based on the appearance of the mutant larvae, such as hedgehog, gurken (German: "cucumbers"), and Krüppel ( "cripple"). Later, researchers identified exactly which gene had been affected by each mutation, thereby identifying a set of genes crucial for Drosophila embryogenesis. The subsequent study of these mutants and their interactions led to important new insights into early Drosophila development, especially the mechanisms that underlie the step-wise development of body segments.
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