Chris Dobson
| Chris Dobson | |
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| Born | Christopher Martin Dobson October 8, 1949 |
| Residence | Cambridge |
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| Thesis | The conformation of lysozyme in solution (1975) |
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Christopher Martin Dobson, FRS, FMedSci (born 8 October 1949) is a British chemist, who is the John Humphrey Plummer Professor of Chemical and Structural Biology in the Department of Chemistry at the University of Cambridge, and Master of St John's College, Cambridge.
Dobson completed a Bachelor of Arts and D.Phil at the University of Oxford (Keble and Merton Colleges).
Dobson's research is largely concerned with protein folding and misfolding, and its links with medical disorders particularly Alzheimer's and Parkinson's diseases. His research interests are focused on protein molecules, and particularly on defining the fundamental principles by which they fold to generate function and biological activity, and yet can misfold to generate toxicity and disease. His studies are highly interdisciplinary and collaborative, and make use of a very wide range of techniques, encompassing theory as well experiment. The Dobson group based at the Department of Chemistry, University of Cambridge is particularly interested in the discovery of the nature, properties, mechanism of formation and biological significance of the ‘misfolded’ amyloid state of proteins. Amyloid-related diseases include whole-body disorders such as the systemic amyloidoses, neuronal disorders such as Alzheimer’s and Parkinson’s diseases, and other organ-specific disorders such as type II diabetes. The major goals are the elucidation of the general molecular principles that underlie this whole family of medical conditions, which are now becoming a major threat to human health and social harmony across the modern world, and the generation of a firm foundation for the rational and effective prevention and treatment of these debilitating and usually fatal conditions. Dobson is an author or co-author of nearly 700 papers and review articles, including more than 30 in Nature and Science, which have been cited over 50,000 times. His current h-index is 110.
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