Chest Creek is a tributary of the West Branch Susquehanna River in Cambria County and Clearfield County, in Pennsylvania, in the United States. It is approximately 40.4 miles (65.0 km) long and flows through Allegheny Township, East Carroll Township, Clearfield Township, Patton, Chest Township, and Elder Township in Cambria County and Westover Township, Chest Township, Newburg, Bell Township, and Maheffy in Clearfield County. Although it is considered by the Pennsylvania Department of Environmental Protection to be impaired by situation, it is a coldwater fishery or a high-quality coldwater fishery throughout its length. The watershed of the creek has an area of 129.22 square miles (334.7 km2).
Chest Creek begins in a valley in Allegheny Township, Cambria County. It flows north for several miles to Bradley Junction, where its valley widens and it turns northeast. The creek picks up the tributary Laurel Lick Run and eventually turns north again and flows along the border between East Caroroll Township and Clearfield Township. It eventually reaches the community of Patton, where it picks up the tributary Little Chest Creek and turns north-northwest, flowing along the border between Chest Township and Elder Township. After a number of miles, the creek receives the tributaries Rock Run and Brubaker Run. A short distance downstream, it leaves Cambria County.
Upon leaving Cambria County, Chest Creek enters Westover Township, Clearfield County. In this township, the creek turns northeast, picking up Rougues Harbor Run and Ashcraft Run. It then passes by the community of Westover. The creek enters Chest Township, Clearfield County and starts meandering. It crosses once and flows parallel to Pennsylvania Route 36 for a number of miles and receives the tributaries Pine Run, Spring Run, Kings Run, Snyder Run, and North Camp Run. The creek eventually passes through the community of Newburg, where it receives Wilson Run and Rattling Run. It then enters Bell Township and turns northwest, flowing parallel to Pennsylvania Route 36. A few miles later, it passes through Maheffy and reaches its confluence with the West Branch Susquehanna River.