The Cherubikon (Greek: χερουβικόν), Cherubic Hymn (χερουβικὸς ὕμνος) or Cherubim Chant (Old Church Sl. Херувімскаѧ пҍснь), is the troparion normally sung at the Great Entrance during the Byzantine liturgy. The hymn is sung in the Eastern Orthodox Church and the Eastern Catholic Churches.
The hymn symbolically incorporates those present at the liturgy into the presence of the angels gathered around God's throne. It concerns the very heart of the Divine Liturgy—the Anaphora, the earliest part which can be traced back to Saint Basil and to John Chrysostom's redaction of Basil's liturgical text.
The trisagion or thrice-holy hymn which was mentioned by John Chrysostom, could only refer to the Sanctus of the Anaphora taken from the Old Testament, from the book of the prophet Isaiah in particular (6:1-3):
[1] And it came to pass in the year in which king Ozias died, that I saw the Lord sitting on a high and exalted throne, and the house was full of his glory. [2] And seraphs stood round about him, each one had six wings, and with two they covered their face, and with two they covered their feet, and with two they flew. [3] And one cried to the other, and they said "Holy, holy, holy is the Lord of hosts! The whole earth is full of His glory!"