Coordinates: 38°14′44″N 85°40′39″W / 38.24560°N 85.67750°W Cherokee Gardens is a residential area six miles east of downtown Louisville, Kentucky USA. The area is a collection of small, unconnected subdivisions along Lexington Road and large estates built just outside Cherokee Park.
The area was deeded to James Southall and Richard Charlton for their part in the French and Indian War. The land remained untouched well into the 1850s because it lay off Frankfort Avenue and Bardstown Road, the two major through routes of the area. In 1851 an alternative route of Frankfort Ave was built for travellers who wanted to avoid the railroad further down in Clifton. The new road was first called 'Shelbyville Branch', today it is called Lexington Road.
Many of Louisville's early 20th Century elite lived in the area, drawn there by the large, undeveloped parcels of land near downtown. Most houses in the area were built from the 1920s to the 1950s, several being designed by noted Louisville residential architect Stratton Hammon.
Cherokee Gardens is bounded by Lexington Road, Cannons Lane, and I-64. As of 2000, the population of Cherokee Gardens was 927 .