Charles Zuker
| Charles S. Zuker | |
|---|---|
| Born | 1957 |
| Citizenship | USA |
| Nationality | Chile |
| Fields | Neuroscience |
| Institutions | UC San Diego 1987-2009, Columbia University 2009-present |
| Alma mater | MIT |
| Doctoral advisor | Harvey Lodish |
Charles S. Zuker is an American molecular geneticist and neurobiologist of Chilean descent. His lab, in collaboration with Nick Ryba at the NIH, have transformed our understanding of mammalian taste. Beginning in the late 1990’s Zuker and Ryba identified and characterized the cells mediating all five basic taste modalities: sweet, sour, bitter, salty and umami. They then demonstrated that individual taste receptor cells are tuned to encode individual taste qualities, and are hardwired to trigger innate behaviors (like attraction to sweet and aversion to bitters). In a set of milestone studies exploring the central coding of taste, and combining molecular genetics, physiology, brain imaging, animal behavior, and optical control of neural circuits, Zuker and collaborators demonstrated that each taste is preferentially represented in its own cortical field in the brain, and that by manipulating the brain fields representing sweet and bitter taste they could directly control an animal’s internal representation, sensory perception, and behavioral actions.
Zuker is an Investigator of the Howard Hughes Medical Institute and a Senior Fellow at the Janelia Research Campus. Zuker is a member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences. After more than 20 years at the University of California, San Diego, he began his appointment at Columbia University in 2009.
Prior to working on mammalian taste, his lab focused on signal transduction pathways in Drosophila melanogaster (fruit fly), including vision, mechanotransduction and thermosensation.
Zuker attended the Universidad Catolica de Valparaiso in Chile, and obtained his Ph.D. from MIT with Harvey Lodish. He did his postdoctoral studies at the University of California, Berkeley with Gerald Rubin.
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