The second Charles Powell Leslie (1769–1831), known also as Charles Powell Leslie II, was Irish member of the UK Parliament for Monaghan (1801–1826) and New Ross (1830–1831). He succeeded his father, Charles Powell Leslie I, in representing Monaghan.
He was married to Anne (née Ryder) from 1791 to her death in 1813, with whom he had three daughters. He married Christina (née Fosbury), with whom he had three sons and four daughters including Charles Powell, John, Christiana, and Prudentia-Penelope.