"Change of Heart" is the second single released by American singer Cyndi Lauper from her second album, True Colors in 1986. The single went gold in the US and peaked at No. 3 in the Billboard Hot 100. The song has become a fan favorite and Lauper still often performs it. Lauper re-recorded it acoustically, and her official site later made it available free as a digital download.

Popular remixes by Shep Pettibone were also released. A music video was filmed in Trafalgar Square in London. It features Lauper and her band performing the song in front of a large group of people.

The Bangles sang background vocals on the original recording.

A live version of the song was released on Lauper's live album/DVD, To Memphis, with Love.

Jimmy Guterman of Rolling Stone magazine said of the song in his album review for True Colors, "..Lauper's trademark hiccuped syllables rest on a cushion of harmonies supplied by the Bangles and transform what is little more than a sophisticated rhythm track with nominal lyrics into a heartfelt declaration of fidelity."

"Change of Heart" debuted on the Billboard Hot 100 at No. 67 and reached a peak position of No. 3 on the issue dated 14 February 1987, spending a total of 17 weeks on the chart. It had similar success in the Hot Dance/Club Play Songs chart, hitting No. 4. The song placed at No. 61 on the year-end chart of 1987. In Canada, the song debuted at No. 88 on the RPM issue dated 13 December 1986. After 10 weeks, it reached a peak position of No. 13 and spent a total of 17 weeks in the chart. In the United Kingdom, "Change of Heart" debuted at No. 96 on the UK Singles Chart and was Lauper's least successful UK single to date, only reaching No. 67. Across Europe, "Change of Heart" peaked at No. 8 in France.

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