The Chandra X-ray Observatory (CXO), previously known as the Advanced X-ray Astrophysics Facility (AXAF), is a Flagship-class space observatory launched on STS-93 by NASA on July 23, 1999. Chandra is sensitive to X-ray sources 100 times fainter than any previous X-ray telescope, enabled by the high angular resolution of its mirrors. Since the Earth's atmosphere absorbs the vast majority of X-rays, they are not detectable from Earth-based telescopes; therefore space-based telescopes are required to make these observations. Chandra is an Earth satellite in a 64-hour orbit, and its mission is ongoing as of 2016^[update].

Chandra is one of the Great Observatories, along with the Hubble Space Telescope, Compton Gamma Ray Observatory (1991–2000), and the Spitzer Space Telescope. The telescope is named after astrophysicist Subrahmanyan Chandrasekhar.

In 1976 the Chandra X-ray Observatory (called AXAF at the time) was proposed to NASA by Riccardo Giacconi and Harvey Tananbaum. Preliminary work began the following year at Marshall Space Flight Center (MSFC) and the Smithsonian Astrophysical Observatory (SAO). In the meantime, in 1978, NASA launched the first imaging X-ray telescope, Einstein (HEAO-2), into orbit. Work continued on the AXAF project throughout the 1980s and 1990s. In 1992, to reduce costs, the spacecraft was redesigned. Four of the twelve planned mirrors were eliminated, as were two of the six scientific instruments. AXAF's planned orbit was changed to an elliptical one, reaching one third of the way to the Moon's at its farthest point. This eliminated the possibility of improvement or repair by the space shuttle but put the observatory above the Earth's radiation belts for most of its orbit. AXAF was assembled and tested by TRW (now Northrop Grumman Aerospace Systems) in Redondo Beach, California.

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