Central Female College, was a women's college located in Lexington, Missouri. The institution was associated with the Methodist Episcopal Church, South and operated from 1869 to 1924.
The college was initially founded as Marvin Female Institute in honor of Bishop E.M. Marvin and was located on South 6th Street. The institution moved to the property of the former Masonic College in 1871 and adopted the name of Central Female College.
Along with seven other women's colleges in Missouri – Stephens, Christian, Lindenwood, Cottey, Howard Payne, William Woods, and Hardin College and Conservatory of Music – Central Female College was one of the original members of Phi Theta Kappa, the international honor society for two-year colleges and program.
After closing, the assets were acquired by Central College, now Central Methodist University in Fayette, Missouri.