Casimir II of Cieszyn (Polish: Kazimierz II cieszyński, Czech: Kazimír II. Těšínský, German: Kasimir II. von Teschen) (c. 1449 – 13 December 1528) was a Duke of Cieszyn since 1477, ruler over Koźle during 1479–1509, since 1493 ruler over Wołów, over Pszczyna during 1498–1517, from 1506 over Opava, Duke of Głogów since 1506 (for life). Also he was Landeshauptmann General of Silesia during 1497–1504 and 1507–1517, since 1517 until his death, Landeshauptmann over the Upper Silesia.
He was the eldest child and only son of Bolesław II, Duke of Cieszyn, by his wife Anna, daughter of Ivan Vladimirovich, Prince of Bielsk.
After the early death of his father in 1452, Casimir II was raised by his uncle Przemysław II, who gave him the town of Bielsko and surrounding villages in 1460, at eleven years of age.
Casimir II's first political intervention was by 1471, when he supported King Władysław II Jagiellon during his conflicts with the Bohemian nobility. Four years later (in 1475), Casimir II he attended to the marriage of Princess Hedwig of Poland (King Casimir IV's daughter) with Duke Georg of Bavaria-Landshut. When Przemysław II died in 1477, Casimir II had enough political experience and could take control over the whole Duchy of Cieszyn without any co-rulers, because all his uncles died without male descendants.