Carboplatin

Carboplatin

Clinical data
Pronunciation	/ˈkɑːrboʊˌplætən/
Trade names	Paraplatin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a695017
Pregnancy category	US: D (Evidence of risk)
Routes of administration	Intravenous
ATC code	L01XA02 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	complete
Protein binding	Very low
Biological half-life	1.1-2 hours
Excretion	renal
Identifiers
IUPAC name cis-diammine(cyclobutane-1,1-dicarboxylate-O,O')platinum(II)
CAS Number	41575-94-4 Y
PubChem CID	498142
DrugBank	DB00958 Y
ChemSpider	8514637 Y
UNII	BG3F62OND5
KEGG	D01363 Y
ChEBI	CHEBI:31355 Y
ChEMBL	CHEMBL288376 N
ECHA InfoCard	100.050.388
Chemical and physical data
Formula	C6H12N2O4Pt
Molar mass	371.249 g/mol
3D model (Jmol)	Interactive image
SMILES C1CC2(C1)C(=O)O[Pt]OC2=O.N.N
InChI InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2 Y Key:OLESAACUTLOWQZ-UHFFFAOYSA-L Y
NY (what is this?)

Carboplatin, sold under the trade name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. It is used by injection into a vein.

Side effects generally occur. Common side effects include low blood cell levels, nausea, and electrolyte problems. Other serious side effects include allergic reactions and increases future risk of another cancer. Use during pregnancy may result in harm to the baby. Carboplatin in the platinum-based antineoplastic family of medications and works by interfering with duplication of DNA.

Carboplatin was patented in 1972 and approved for medical use in 1986. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about 26.49 to 37.37 USD per 450 mg vial. In the United Kingdom that amount costs the NIH about 160.00 pounds.

Relative to cisplatin, the greatest benefit of carboplatin is its reduced side effects, particularly the elimination of nephrotoxic effects. Nausea and vomiting are less severe and more easily controlled.