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Cannabis use disorder

Cannabis use disorder
Classification and external resources
Specialty psychiatry
ICD-10 F12
ICD-9-CM 304.3
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Cannabis use disorder (CUD) (Also known as cannabis or marijuana addiction) is defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and ICD-10 published by World Health Organization as the continued use of cannabis despite clinically significant impairment, ranging from mild to severe.

Marijuana use and abuse has symptoms that affect behavior, physical, cognitive, and psychosocial aspects of a person's life. Symptoms include agitation, bloodshot eyes, challenges in problem solving, and paranoia.

Cannabis use is associated with comorbid mental health problems, such as mood and anxiety disorders, and discontinuing cannabis use is difficult for some users. Psychiatric comorbidities are often present in dependent cannabis users including a range of personality disorders.

The use of cannabis at a young age such as the teenage years, can have serious impacts on depression and anxiety in youth and later in life. There is evidence that cannabis use during adolescence, at a time when the brain is still developing, may have deleterious effects on neural development and later cognitive functioning. The brain is not completely developed until a person reaches the age range of 22-27. Excessive use of marijuana can cause harm to this development.. Based on an annual survey data 7 percent of high school seniors that smoke daily function at a lower rate in school than students that do not. The sedating and anxiolytic properties of THC in some users might make the use of cannabis an attempt to self-medicate personality or psychiatric disorders.

Prolonged marijuana use produces both pharmacokinetic changes (how the drug is absorbed, distributed, metabolized, and excreted) and pharmacodynamic changes (how the drug interacts with target cells) to the body. These changes require the user to consume higher doses of the drug to achieve a common desirable effect (known as a higher tolerance), reinforcing the body's metabolic systems for eliminating the drug more efficiently and further downregulating cannabinoid receptors in the brain. These effects compound themselves in that the chronic user must consume more frequently to overcome the accelerated clearance, and higher doses to overcome the blunted response to receptor activation.


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