"Can't Tell Me Nothing" is a song by American hip-hop recording artist Kanye West. It was released on May 15, 2007 as the lead single of his third studio album, Graduation. The song was produced by Kanye West and Atlanta record producer DJ Toomp. It received acclaim from music critics and was listed amongst the best tracks of the year by several publications. "Can't Tell Me Nothing" was nominated for Best Rap Song at the 50th Grammy Awards, but lost to another one of West's songs, "Good Life".

The cover art of the single was designed by the Japanese artist Takashi Murakami. Though "Can't Tell Me Nothing" didn't impact pop radio as significantly as the album's subsequent singles, West took pride in the fact that he had attained his very first street anthem with the song. The song is featured as the sixth track on Now That's What I Call Music! 26. It was nominated for "Track of the Year" at the 2007 BET Hip Hop Awards. It was also featured in the movie The Hangover.

"Can't Tell Me Nothing" features slow, moody synth-driven production, exemplifying the new sonic direction that would come to dominate much of Graduation. West stated that he drew inspiration from arena rock bands such as The Rolling Stones and Led Zeppelin, elaborating that the song's chords are akin to that of a rock melody. He also explained that, with the track, he wanted to make anthemic music and create a theme song for the people. The song contains audio samples of ad-libs provided by Young Jeezy as well as background vocals provided by Connie Mitchell of the Australian electronic group Sneaky Sound System.

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