Cadzow Castle, now in ruins, was constructed between 1500 and 1550 on the site of an earlier royal castle, one mile south-east of the centre of Hamilton, South Lanarkshire, Scotland. The town of Hamilton was formerly known as Cadzow or Cadyou (Middle Scots: Cadȝow, the "ȝ" being the letter yogh), until renamed in 1455 in honour of James Hamilton, 1st Lord Hamilton. The castle sits above a gorge overlooking the Avon Water in what is now Chatelherault Country Park, but was previously the hunting and pleasure grounds of the Duke of Hamilton's estate of Hamilton Palace. The ruin is a category B listed building and a Scheduled Ancient Monument.
The ancient kings of Strathclyde are said to have had a hunting lodge at Cadzow, prior to that kingdom's assimilation into Scotland in the 12th century. The original Cadzow Castle was built in the 12th century as an occasional royal residence for King David I (1124–1153). Royal charters of David's reign were issued from here as early as 1139. His successors Alexander II, Alexander III and others down to Robert the Bruce also used the castle, primarily as a hunting lodge. It is possible that this earlier castle was on an alternative site at NS729548, now known as Castlehill, although the area is now a housing estate.