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C. Walton Lillehei

Clarence Walton Lillehei
Born (1918-10-23)October 23, 1918
Minneapolis, Minnesota
United States
Died July 5, 1999(1999-07-05) (aged 80)
Education University of Minnesota
Known for being first to pioneer open heart surgery.
Medical career
Profession Surgeon
Institutions University of Minnesota
Specialism cardiothoracic surgery
Research open-heart surgery
Notable prizes Harvey Prize in Science and Technology
Gairdner Foundation International Award (1963)

Clarence Walton "Walt" Lillehei (October 23, 1918 – July 5, 1999), was an American surgeon who pioneered open-heart surgery, as well as numerous techniques, equipment and prostheses for cardiothoracic surgery.

Clarence (often referred to as "Walt") Lillehei was born in Minneapolis, Minnesota, the son of Dr. Clarence Ingvald Lillehei (1892-1973) and Elizabeth Lillian (Walton) Lillehei (1891-1973). He attended the University of Minnesota at the age of 17. He earned 4 degrees at the University of Minnesota, including his B.S. (with distinction) in 1939, his M.D. (Alpha Omega Alpha) in 1942, his M.S. in physiology in 1951, and his Ph.D. in surgery in 1951.

A Department of Surgery professor at the University of Minnesota from 1951 to 1967, Lillehei participated in the world's first successful open-heart operation using hypothermia. In 1944, Alfred Blalock at Johns Hopkins University had begun successfully performing surgery on the great vessels around the heart to relieve the symptoms of tetralogy of Fallot, demonstrating that heart surgery could be possible. Young and brash, Lillehei completed, at age 35, the first successful surgical repair of the heart on September 2, 1952. That historic operation, using hypothermia, was led by his longtime friend and colleague, Dr. F. John Lewis.

Hypothermia, however, only gave a brief window (up to 10 minutes) during which surgery could be performed and was therefore not suited for complex congenital defects within the heart. To resolve this problem, Lillehei performed surgeries using cross-circulation, in which a donor was hooked up nearby to take up the pumping and oxygenation functions of the patient as he was being operated on. Using this technique, Lillehei led the team that performed successful repair of a ventricular septal defect on March 26, 1954. Although the repair was successful, the patient, 13-month-old Gregory Glidden, died 11 days later of suspected pneumonia. Lillehei and his team continued to use cross-circulation for a total of 44 open-heart operations in the following year, of which 32 patients survived. These surgeries included the first repairs of the atrioventricular canal and tetralogy of Fallot. In July of that year, a successful operation was performed on patient Michael Eugene Shaw (aka Mike Shaw) of Litchfield, Minnesota.


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