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C. C. Little

C. C. Little
Clarence Cook Little.jpg
Born Clarence Cook Little
October 6, 1888
Brookline, Massachusetts
Died December 22, 1971(1971-12-22) (aged 83)
Occupation academic administrator, researcher

Clarence Cook "C.C." Little (October 6, 1888 – December 22, 1971) was an American genetics, cancer, and tobacco researcher and academic administrator.

He was born in Brookline, Massachusetts and attended Harvard University after his secondary education at the Noble and Greenough School. While studying under W. E. Castle, Little began his work with mice, focusing on inheritance, transplants, and grafts. He also was an assistant dean and secretary to the president. His most important research occurred at Harvard, including what some call his most brilliant work, "A Mendelian explanation for the inheritance of a trait that has apparently non-Mendelian characteristics". His observations on transplant rejection became codified into the "five laws of transplant immunology" by George Snell. Little developed the "DBA (Dilute, Brown and non-Agouti)" strain of mice while at Harvard. For his research, he received the 1978 Cancer Research Institute William B. Coley Award.

Little received an A.B. from Harvard University in 1910, an M.S. in 1912, and D.Sc. in 1914 in zoology, with special focus in the new science of genetics.

During World War I Little served in the U.S. Army Signal Corps, attaining the rank of Major. Following the war he spent three years at the Cold Spring Harbor Laboratory. In 1921 he helped found the American Birth Control League with Margaret Sanger and Lothrop Stoddard.


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