Butylscopolamine

Hyoscine butylbromide

Clinical data
Trade names	Buscopan
Pregnancy category	AU: B2
Routes of administration	By mouth, rectal, intravenous
ATC code	A03BB01 (WHO)
Legal status
Legal status	AU: S2 (Pharmacy only) UK: General sales list (GSL, OTC)
Pharmacokinetic data
Bioavailability	<1%
Protein binding	Low
Biological half-life	5 hours
Excretion	Renal (50%) and fecal
Identifiers
IUPAC name [7(S)-(1α,2β,4β,5α,7β)]-9-butyl-7-(3-hydroxy- 1-oxo-2-phenylpropoxy)-9-methyl-3-oxa- 9-azonitricyclo[3.3.1.0(2,4)]nonane
CAS Number	149-64-4 Y
PubChem CID	160883
DrugBank	DB09300 Y
ChemSpider	16736107 Y
UNII	2Z3E1OF81V
ChEMBL	CHEMBL1256901 N
ECHA InfoCard	100.005.223
Chemical and physical data
Formula	C21H30NO4+
Molar mass	360.467 g/mol
3D model (Jmol)	Interactive image
SMILES [Br-].OC[C@H](c1ccccc1)C(=O)O[C@@H]2C[C@@H]3[C@H]4O[C@H]4[C@H](C2)[N+]3(C)CCCC
InChI InChI=1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15-,16-,17-,18+,19-,20+,22?;/m1./s1 Y Key:HOZOZZFCZRXYEK-GSWUYBTGSA-M Y
NY (what is this?)

Hyoscine butylbromide, also known as scopolamine butylbromide and sold under the brandname Buscopan, is a medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. It is also used to improve respiratory secretions at the end of life. Hyoscine butylbromide can be taken by mouth, injection into a muscle, or into a vein.

Side effects may include sleepiness, vision changes, triggering of glaucoma, and severe allergies. Sleepiness however, is uncommon. It is unclear if it is safe in pregnancy. It is an anticholinergic agent, which does not have much effect on the brain.

It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is not available in the United States. The wholesale cost in the developing world is 0.004 to 0.11 USD per pill as of 2014. It is manufactured from hyoscine which occurs naturally in the plant deadly nightshade.

Hyoscine butylbromide is effective in treating crampy abdominal pain.

Hyoscine butylbromide is effective in reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.

It is also used during abdominal or pelvic MRI or CT scans to improve the quality of pictures.