"Bust It Baby" is a single by American rapper Plies released on January 25, 2008. It is the first single from Plies' second album, Definition of Real. This was featured as a bonus track on his album, while "Bust It Baby Pt. 2" is the official track on the album. It features R&B-Pop singer Ne-Yo.

The song features a noticeable sample of Janet Jackson's 1990 single "Come Back to Me", a #2 hit from her 1989 album "Janet Jackson's Rhythm Nation 1814". Janet also featured on the song's official remix.

"Bust It Baby (Part 2)" is the second part of the two single release of "Bust It Baby", making it the first "double single." On the R&B/Hip Hop chart, "Bust It Baby Pt. 2" has so far peaked at #2, surpassing the original "Bust It Baby". It is his second top 10 hit on the Billboard Hot 100 and also his biggest hit on the Billboard Hot 100 to date, peaking at #7 thus far, surpassing the #9 peak of "Shawty" in 2007, and tying for Slip-n-Slide Records' highest placing on the Hot 100 (the other SNS single to reach that peak was Trick Daddy's 2004 single "Let's Go" featuring Lil Jon and Twista). In New Zealand, the song jumped from #22 to #9 in its second week on the chart.

The music video directed by Plies himself debuted on BET's Rap City on April 28, 2008.DJ Khaled and Rick Ross and Ace Hood make cameos. It debuted on 106 & Park on May 1, 2008. "Bust It Baby Pt. 2" has had multiple number ones on 106 & Park. It stayed on the countdown for 35 days.

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