Burkhard von Weisbriach (died 1466) was a German Roman Catholic cardinal and Prince-Archbishop of Salzburg from 1461 until his death.
He was probably born at Weißpriach Castle in the Salzburg Lungau region about 1420 or 1423, the son of Burkhard von Weisbriach the Elder and Anna of Liechtenstein-Kastelkorn. The Lords of Weißbriach had served as ministeriales and local administrators of the Salzburg archbishops for centuries. Burkhard enrolled in the University of Vienna in 1437, studying theology and law. After he completed his education, he traveled to Rome, where he became a protonotary apostolic.
He became a canon of Salzburg Cathedral in 1448 and its provost in 1452. Throughout the 1450s, he served as an envoy from the Habsburg emperor Frederick III and his brother Archduke Albert VI of Austria to the court of Pope Nicholas V in Rome. He repeatedly tried to alleviate the ongoing fratricidal conflict between the Habsburg rulers, though to no avail. In March 1459, the emperor sent him to Siena to congratulate Pope Pius II on his recent election to the papacy. In November, he intervened in the Council of Mantua. In the conflict of Cardinal Nicholas of Cusa, Prince-Bishop of Brixen with Archduke Siegmund of Austria-Tyrol, he likewise sided with the Habsburg dynasty.