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Bromocresol purple

Bromocresol purple
Skeletal formula of bromocresol purple in cyclic form
Ball-and-stick model of the bromocresol purple molecule in cyclic form
Names
IUPAC name
4,4'-(1,1-Dioxido-3H-2,1-benzoxathiole-3,3-diyl)-bis(2-bromo-6-methylphenol)
Other names
5′,5″-Dibromo-o-cresolsulfonephthalein
Bromcresol purple
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.003.716
PubChem CID
Properties
C21H16Br2O5S
Molar mass 540.22 g·mol−1
Appearance Purple powder
Melting point 241 to 242 °C (466 to 468 °F; 514 to 515 K) (decomposition)
< 0.1 %
Hazards
R-phrases (outdated) R36/37/38
S-phrases (outdated) S26, S36
NFPA 704
Flammability code 0: Will not burn. E.g., water Health code 1: Exposure would cause irritation but only minor residual injury. E.g., turpentine Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Bromocresol purple (BCP) or 5′,5″-dibromo-o-cresolsulfophthalein, is a dye of the triphenylmethane family (triarylmethane dyes) and a pH indicator. It is colored yellow below pH 5.2, and violet above pH 6.8. In its cyclic sulfonate ester form, it has a pKa value of 6.3, and is usually prepared as a 0.04% aqueous solution.

Bromocresol purple is used in medical laboratories to measure albumin. Use of BCP in this application may provide some advantage over older methods using bromocresol green. In microbiology, it is used for staining dead cells based on their acidity, and for the isolation and assaying of lactic acid bacteria.

In photographic processing, it can be used as an additive to acid stop baths to indicate that the bath has reached neutral pH and needs to be replaced.

Bromocresol purple milk solids glucose agar is used as a medium used to distinguish dermatophytes from bacteria and other organisms in cases of ringworm fungus (T. verrucosum) infestation in cattle and other animals.

Similar to bromocresol green, the structure of bromocresol purple changes with pH. The low pH (acidic) form is yellow in solution and the high pH (basic) form is purple; the sultone (cyclic sulfonic ester) is the acidic form in the following equilibrium.


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Wikipedia

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