Brodmann area 46
| Brodmann area 46 | |
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| Details | |
| Identifiers | |
| Latin | Area frontalis media |
| NeuroLex ID | Brodmann area 46 |
| FMA | 68643 |
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Anatomical terms of neuroanatomy
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Brodmann area 46, or BA46, is part of the frontal cortex in the human brain. It is between BA10 and BA45.
BA46 is known as middle frontal area 46. In the human brain it occupies approximately the middle third of the middle frontal gyrus and the most rostral portion of the inferior frontal gyrus. Brodmann area 46 roughly corresponds with the dorsolateral prefrontal cortex (DLPFC), although the borders of area 46 are based on cytoarchitecture rather than function. The DLPFC also encompasses part of granular frontal area 9, directly adjacent on the dorsal surface of the cortex.
Cytoarchitecturally, BA46 is bounded dorsally by the granular frontal area 9, rostroventrally by the frontopolar area 10 and caudally by the triangular area 45 (Brodmann-1909). There is some discrepancy between the extent of BA8 (Brodmann-1905) and the same area as described by Walker (1940)
The DLPFC plays a role in sustaining attention and working memory. Lesions to the DLPFC impair short-term memory and cause difficulty inhibiting responses. Lesions may also eliminate much of the ability to make judgements about relevance of a stimulus, as well as causing problems in organization.
The DLPFC has recently been found to be involved in exhibiting self-control.
The dorsolateral prefrontal cortex is one of the few areas deactivated during REM sleep.
Research in enhancing working memory has been done by the use of transcranial direct current stimulation (tDCS) to the DLPFC which is believed to excite the shift in membrane potential in either a depolarization or hyperbolizing direction. So the desired effect of this method would be to strengthen synaptic transmission for long-term potentiation (LTP) during post stimulation of the DLPFC, a key to learning.
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