"Blues After Hours" is a 1948 instrumental by West Coast blues guitarist Pee Wee Crayton. It was his first single and the most successful of his three chart entries. "Blues After Hours" went to the number one spot on the Billboard magazine's Race Records charts.

According to Crayton, "Blues After Hours" was inspired by T-Bone Walker and developed while he was playing at the New Orleans Swing Club in San Francisco. During his first recording session for Jules Bihari, Crayton began to play the song and Bihari decided to record it. Crayton protested, saying that the song was unfinished. Bihari countered: "Play anything." "So I started playing and ideas just came. I was making T-Bone's stuff into what little I knew. That turned out to be one of the biggest records I ever had."

Backing Crayton (guitar) are: Buddy Floyd (tenor saxophone), David Lee Johnson (piano), Bill Davis (bass), Candy Johnson (drums), plus additional unidentified musicians. One source calls "Blues After Hours" "a barely disguised takeoff on 'After Hours'", a 1940 instrumental by Erskine Hawkins and His Orchestra (Bluebird 10879), although Crayton's song features electric guitar, whereas the earlier song does not.

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