Blachernae (Greek: Βλαχέρναι) was a suburb in the northwestern section of Constantinople, the capital city of the Byzantine Empire. It is the site of a water source and a number of prominent churches were built there, most notably the great Church of St. Mary of Blachernae (Panagia Blacherniotissa), built by Empress Pulcheria in c. 450, expanded by Emperor Leo I (r. 457–474) and renovated by Emperor Justinian I (r. 527–565) in the 6th century.
The Romanian philologist Ilie Gherghel, wrote a study about Blachernae and concluded that it possibly derived from the name of a Vlach (sometimes written as Blach or Blasi), who came to Constantinople from the lower Danube, a region named today Dobruja. Gherghel compared data from old historians like Genesios and from the Greek lexicon Suidas and mentioned the existence of a small colony of Vlachs in the area of today Blachernae. Similar opinions were sustained by Lisseanu
The quarter is recorded as regio XIV in the early 5th-century Notitia Urbis Constantinopolitanae, where it is recorded as being enclosed by a wall of its own. The quarter was connected to the city proper at the construction of the Theodosian Walls, but the Church of St. Mary remained outside of the walls until 627, when Emperor Heraclius (r. 610–641) built another wall to enclose it. By that time, the church had become the major Marian shrine of the city, and the second-most important church in Constantinople after Hagia Sophia, if only because the emperors' residence was nearby. In 1347, Emperor John VI Kantakouzenos (r. 1347–1354) was crowned there, instead of at Hagia Sophia.