Biological engineering or bio-engineering (including biological systems engineering) is the application of concepts and methods of biology (and secondarily of physics, chemistry, mathematics, and computer science) to solve real-world problems related to life sciences or the application thereof, using engineering's own analytical and methodologies and also its traditional sensitivity to the cost and practicality of the solution(s) arrived at. In this context, while traditional engineering applies physical and mathematical sciences to analyze, design and manufacture inanimate tools, structures and processes, biological engineering uses primarily the rapidly developing body of knowledge known as molecular biology to study and advance applications of organisms and to create biotechnology. This may eventually include the possibility of biologically engineering machines and 3D printing that re-order matter at a molecular scale. Physicist Richard Feynman theorized about the idea of a medical use for these biological machines, introduced into the body, to repair or detect damages and infections. . Feynman and Albert Hibbs suggested that it might one day be possible to (as Feynman put it) "swallow the doctor". The idea was discussed in Feynman's 1959 essay There's Plenty of Room at the Bottom.