William Ray "Bill" Upton (June 18, 1929 – January 2, 1987) was a Major League Baseball pitcher who made two relief appearances in 1954 with the Philadelphia Athletics. He batted and threw right-handed.

Upton had no decision in either of his appearances, with a 1.80 ERA, allowing one earned run in five innings pitched.

He was born in Esther, Missouri and died in San Diego, California. His brother Tom played in the big leagues from 1950 to 1952.