Beri-beri
| Beriberi | |
|---|---|
 |
|
| A sufferer from beriberi at the beginning of the 20th century in Southeast Asia. | |
| Classification and external resources | |
| Specialty | Neurology, cardiology, pediatrics |
| ICD-10 | E51.1 |
| ICD-9-CM | 265.0 |
| DiseasesDB | 14107 |
| MedlinePlus | 000339 |
| eMedicine | ped/229 med/221 |
| Patient UK | Beriberi |
| MeSH | D001602 |
Beriberi refers to a cluster of symptoms caused primarily by thiamine (vitamin B1) deficiency. Beriberi has conventionally been divided into three separate entities, relating to the body system mainly involved (peripheral nervous system or cardiovascular) or age of person (like infantile). Beriberi is one of several thiamine-deficiency related conditions, which may occur concurrently, including Wernicke's encephalopathy (mainly affecting the central nervous system), Korsakoff's syndrome (amnesia with additional psychiatric manifestations), and Wernicke-Korsakoff syndrome (with both neurologic and psychiatric symptoms).
Historically, beriberi has been common in regions where what is variously referred to as polished or white rice forms a major part of the diet, which has its husk removed to extend its shelf life and palatability but has the side effect of removing the primary source of thiamine. It was not known until the end of the 19th century that polishing rice was associated with beriberi.
Symptoms of beriberi include weight loss, emotional disturbances, impaired sensory perception, weakness and pain in the limbs, and periods of irregular heart rate. Edema (swelling of bodily tissues) is common. It may increase the amount of lactic acid and pyruvic acid within the blood. In advanced cases, the disease may cause high-output cardiac failure and death. Symptoms may occur concurrently with those of Wernicke's encephalopathy, a primarily neurological thiamine-deficiency related condition.
Beriberi is divided into four categories as follows. The first three are historical and the fourth, gastrointestinal beriberi, was recognized in 2004:
Dry beriberi causes wasting and partial paralysis resulting from damaged peripheral nerves. It is also referred to as endemic neuritis. It is characterized by:
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