Benedetto I Zaccaria (c. 1235 – 1307) was an Italian admiral of the Republic of Genoa. He was the Lord of Phocaea (from 1288) and first Lord of Chios (from 1304), and the founder of Zaccaria fortunes in Byzantine and Latin Greece. He was, at different stages in his life, a diplomat, adventurer, mercenary, and statesman.
Benedetto was the second son of Fulcone Zaccaria and one of his wives: Giulietta or Beatrice. Benedetto assisted his brothers Manuele and Nicolino, his cousin Tedisio, and his son Paleologo in their commercial enterprises.
Benedetto was captured by the Venetians in a battle off Tyre in 1258. In 1264, he was sent as a Genoese ambassador to the Byzantine court of Michael VIII Palaiologos. Although his mission was unsuccessful, his acquaintance with the emperor would stand him in good stead. After eleven years of negotiations which resulted in a renewed accord between the Empire and Genoa, Benedetto re-appeared in Constantinople with his brother Manuele in 1275. Benedetto married one of the emperor's sisters, while Manuele received control over the valuable alum mines of Phocaea. This was an extremely lucrative business, especially after Manuele acquired a near-monopoly after persuading Michael VIII to prohibit the import of alum from the Black Sea, even though this trade was also in the hands of Genoese merchants.
As an agent of the emperor, Benedetto acted as an ambassador to Peter III of Aragon in 1280–1282, and took part in the negotiations that led to the Byzantine–Aragonese alliance and the outbreak of the War of the Sicilian Vespers that ended the threat of an invasion of Byzantium by Charles I of Anjou.