"Baby by Me" is the official first single by US rapper 50 Cent from his fourth album Before I Self Destruct. It was commercially released on September 10, 2009. The song is produced by Polow da Don and William Tyler, and written by Curtis Jackson, Jamal Jones, William Tyler and Shaffer Smith. It features vocals by R&B singer Ne-Yo.

"Baby By Me" is a hip hop song by American rapper 50 Cent appearing on his fourth officially released studio album Before I Self Destruct, and was released as the first official single from the album. The single was announced to be released on radio on September 10, 2009 at 10:00 pm by Hot 97's Funkmaster Flex and thisis50.com. A couple hours later, the song was then uploaded onto 50 Cent's MySpace page.

There are two versions of the song, the original version features singer Jovan Dais and the remix version features Ne-Yo. Both versions were released online simultaneously. The official single version will be the remix version which features Ne-Yo. The remix is also featured on his new album.

The album version of the song was the one where you don't even know the singer," 50 told DJ Whoo Kid over the weekend on Sirius XM Radio. "I did the reference in the studio. It's a little more visual. Ne-Yo lightened it up a little bit and made it ready for radio. It works. I gotta sift through and see what I'm gonna put on the album. The Ne-Yo record is a stronger radio version.

The single was made available to download on Amazon and iTunes on October 26, 2009.

The music video for "Baby by Me" was shot in mid October and features Kelly Rowland as 50 Cent's love interest. 50 ran into the Destiny's Child co-founding member when he was presenting at the Los Premios MTV Latinoamérica 2009 awards show in Los Angeles, and it occurred to him to snag the singer for his video, which was set to roll production just two days later.

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